In the second flip of the night, United States networks called a former member of Bill Clinton's cabinet, Democrat Donna Shalala, as victor of a House seat in Florida, where she takes the place of Republican Ileana Ros-Lehtinen, who is retiring.
But with his party losing its majority in the House, the results represented a bitter setback for Trump after a campaign that became a referendum on his leadership.
Drawing attention like few other midterm contests, the election has pitted competing visions of the country against each other, with race often being front and centre, punctuated by two racially tinged crimes.
Likely House outcome: Democrats take control.
Democrats faced a far more hard challenge in the Senate, where they were nearly exclusively on defence in rural states where Mr Trump remains popular. According to Gallup, 66% of Republicans or "Republican leaners" are "very or somewhat worried" about what would happen with a Democratic majority in the House or Senate-while 34% are "not too or not at all anxious". Several television networks, including the president's favorite Fox News Channel, yanked a Trump campaign advertisement off the air on the eve of the election, determining that its portrayal of a murderous immigrant went too far. Moscow denies meddling and Trump denies any collusion.
Democrats were riding to victory Tuesday with strong support from women turned off by Trump's bullying style and among suburban voters with higher incomes and education levels.
"We will have a responsibility to find our common ground where we can, stand our ground where we can't", Pelosi said. Republican Brian Kemp, also secretary of state in Georgia, is running the election as well as running against Democrat Stacey Abrams.
Trump - a 72-year-old former reality TV star and businessman-turned-politician - had hardened his rhetoric down the stretch on issues that appealed to his conservative core supporters, issuing warnings about a caravan of Latin American migrants headed to the border with Mexico and condemnations of liberal American "mobs".
Manchester United manager Jose Mourinho taunts Juventus crowd
Bonucci floated a ball over the top of the defense and Ronaldo watched it over his shoulder before volleying into the top right corner.
Many Democrats, already benefiting from anti-Trump enthusiasm, focused on bread-and-butter issues like maintaining health insurance protections for people with pre-existing medical conditions and safeguarding the Social Security retirement and Medicare healthcare programmes for senior citizens.
If the Republicans hold onto those east coast seats the Democrats will put their hopes in seats in Texas, Arizona, California and Washington.
However, only 1 in 5 voters selected the economy as the most important issue in the election this year, perhaps limiting the benefit of this issue for the ruling Republican Party.
Representative-elect Jennifer Wexton, a Democrat from Virginia, center, speaks during an election night rally in Dulles, Virginia, U.S., on Tuesday, Nov. 6, 2018.
As for the legislature, Democrats needed to flip four seats in the state House and six in the state Senate to break the Republican supermajority.
The top race in Tennessee is between Republican U.S. Rep. Marsha Blackburn and Democrat Phil Bredesen for Tennessee's open U.S. Senate seat.
Some of the campaign's biggest Democratic stars lost.
Voting finished in IN and Kentucky, as well as in most of Florida, Georgia and Virginia.
Captain Kane happy to honour Rooney in England farewell
Over a period I've tried to approach things differently, and some of those decisions are a bit risky; some have paid off, some won't.
All 435 House of Representative seats are in play.
Democrats failed to defeat a vulnerable incumbent in Kentucky, where Republican Rep. Andy Barr won over former Marine fighter pilot Amy McGrath.
Preliminary exit poll results reported by ABC News showed that 18- to 29-year-olds accounted for 13 percent of voters nationally, up from 11 percent in 2014. Some high profile senators are expected to be among that growing pool of candidates in the Democratic presidential primary.
When he was elected, one of his first policies was instituting a travel ban from several Muslim-majority countries, which was upheld by the US Supreme Court.
But for those wondering if a "blue wave" will increase the likelihood of a Trump impeachment, they might be surprised to know that Trump impeachment odds have held steady in regards to betting on political prediction markets.
But mid-morning he tweeted to knock down what he said were rumors that Republican Senate candidate Josh Hawley left the arena in Cape Girardeau, Mo., where Trump held a rally to support him.
In an interview with ABC on Monday, the president said he wished he had taken "a much softer tone" throughout his presidency.
Manchin defeated Republican Patrick Morrisey, the state's attorney general.
Alexandria Ocasio-Cortez to be youngest woman ever elected to Congress
It will also feature the first Native American women, the first Muslim women and the youngest woman ever elected to Congress . We'd been hearing for months about the record number of women running for office, and last night, voters turned out for them.
Democrats also could recapture governorships in several battleground states such as Michigan, Wisconsin and OH, a potential help for the party in those states in the 2020 presidential race. "His actions, his verbage, he's clearly the focal point", said Tim Phillips, president of the Koch-backed Americans for Prosperity, which has poured millions into certain races this cycle to help preserve the Republican majority.