The large lead allowed Hall to enjoy the rousing reception she received on her victory march up to the final hole, where a three-putt bogey was academic.
She birdied the third, sixth, eighth, and 11th holes, and dropped her first shot of the major on the par-3 12th, a bogey.
"I can't believe how many of you fans came out to support me, I am so grateful".
Georgia was born during the 1996 Masters won by Englishman Nick Faldo.
She became the first English player of either sex to win a major at Royal Lytham since Tony Jacklin won the 1969 British Open.
Phatlum's playing partner Georgia Hall of England is one shot off the lead and South Korea's Ryu So-yeon is one shot behind Hall.
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Hall, who received a check of $490,000, became the first English major victor since Karen Stupples won this event in 2004, and the fourth overall, along with Laura Davies and Alison Nicholas.
"I don't know what it is but the bigger the competition the more enjoyable and fun it is", added Hall when asked about her capacity to play big events such as this event a year ago and the Solheim Cup well.
She stamped her authority with three birdies in a four-hole stretch to beat Thailand's Pornanong Phatlum by two strokes at Royal Lytham & St Annes.
However, a double bogey from Phatlum on the 17th sent Hall three clear, giving her plenty of breathing space to complete a famous victory, finishing on 17-under for the tournament.
Hall played safe in three-putting from distance to finish on 17-under 271.
So Yeon Ryu would finish in 3rd position at 13 under, four from the victor and two behind Phatlum.
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"I was loving it deep down, hitting the shots under pressure, " said Hall, who barely showed any emotions all round. He had a four-shot lead and faced a 15-foot birdie putt on the final hole that would only determine his margin of victory. I'm so happy she win, " the Thai said.
"I was so confident coming into this event after past year". Then, when Hall rolled in a 10-foot birdie putt at No. 13, they were tied for the first time since the first hole. "I don't get much in America but this is home for me and it's so nice to play in England in front of a home crowd". The Thai finished runner up for the fifth time in her career, which is also her career best in a major championship.
"I just had to stay calm and patient".
After not qualifying for the ANA Inspiration, Hall made the cut in the following two majors and then finished a brilliant tied-third in the Women's British Open at Kingsbarns before earning another top-10 finish in the Evian Championship.
And no countrywomen has ever accomplished the biggest feat in her sport at such a young age - with one of the great final rounds by any European golfer, to boot.
Also the 2014 and 2015 victor at TPC Twin Cities, the 57-year-old Perry matched Hale Irwin's tournament record of three victories in the final edition of the event that started in 1993 at Bunker Hills.
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