While Soros and Orban where once close, with Soros funding Orban's education, they parted ways as Orban drifted rightwards politically.
Moving operations out of Budapest will have a significant impact on the more than 100 staff based there, most of whom are engaged in global grant making.
The 87-year-old worked as a trader and analyst before establishing Soros Fund Management in 1969.
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Earlier against Soros and his Foundation in Hungary was launched large-scale campaign.
"It started with intimidation in the media, and then it got to members of our staff and partners and friends being spied on by agents", he told Newsweek.
Orban's Fidesz party won last month's election in a landslide, and he campaigned on a platform that was criticized for peddling far-right and right-wing rhetoric.
'Stop Soros': Orban campaigned on a law known as "Stop Soros" created to hobble non-government organizations such as the OSF, reports the BBC.
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"We are going to reaffirm those elements of our sovereignty which are under attack", Orban spokesman Zoltan Kovacs said in a statement.
Ironically, Orban himself received a Soros scholarship to go to Oxford University in 1989.
In February, Israeli Prime Minister Benjamin Netanyahu spoke out at a meeting with Likud ministers and claimed that Soros was behind Israeli protests that were critical of the government's plan to deport African migrants. But during the 1990s, Orban's politics shifted sharply to the nationalist right.
Hungarian Prime Minister Viktor Orban has blamed Soros, a Hungarian-born U.S. financier, for a host of ills and is planning to tighten a crackdown on non-governmental organisations (NGOs) under legislation dubbed the "Stop Soros" bill. The liberal media has attempted to portray the Hungarian governments efforts against the foundation's activities, as anti-Semitic, referring to alleged similar activities prior to the Second World War.
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