Four Royal Air Force Tornado GR4s joined the co-ordinated missile strikes at 2am, launching Storm Shadow missiles at a base 15 miles west of Homs.
The strikes were conducted with the United States and France.
May said the missile strike was created to minimize any civilian casualties and was not an attempt to change the Syrian government.
"This is not about intervening in a civil war".
May has repeatedly said that the missile strike on Syria was not about "regime change".
Britain's defense ministry said initial indications were that the precision weapons and meticulous target planning had "resulted in a successful attack".
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He also conceded it was sweet to triumph in a country where some critics claimed his purist principles couldn't flourish. He won three league titles with Barcelona and twice lifted the Champions League trophy during his Camp Nou reign.
The PM has not ruled out fresh action if Bashar Assad's regime continues to attack its own people.
Theresa May will say: "Over the weekend I have spoken to a range of world leaders, including Chancellor Merkel, Prime Minister Gentiloni, Prime Minister Trudeau, Prime Minister Turnbull and European Council President Donald Tusk".
French President Emmanuel Macron said the strikes had been limited so far to Syria's chemical weapons facilities.
"And while this action is specifically about deterring the Syrian Regime, it will also send a clear signal to anyone else who believes they can use chemical weapons with impunity".
But she also drew a link with the nerve agent attack on Russian former spy Sergei Skripal and his daughter Yulia in Salisbury.
Mr Johnson said Mrs May will be making a statement in the House of Commons on Monday and it will give parliamentarians a chance to hold the executive to account.
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The pub chain said the move also takes into account recent concerns over the misuse of personal data and the addictive nature of social media.
"I have done so because I judge this action to be in Britain's national interest".
Yesterday Prime Minister Theresa May insisted the military action was "legal" and defended the decision to go ahead without securing the backing of Parliament.
May is not obliged to win parliament's approval before ordering military action, but a non-binding constitutional convention to do so has been established since a 2003 vote on joining the US -led invasion of Iraq. But 46% still believed she was better than Jeremy Corbyn on dealing with an global crisis, with just 26% backing the Labour leader.
"Bombing can not substitute for diplomacy", he said.
"It was both right and legal to take military action together with our closest allies to alleviate further humanitarian suffering by degrading the Syrian regime's chemical weapons capability", May said.
He reiterated that Canada condemns the use of chemical weapons in Ghouta.
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Over 100 missiles were fired on the morning of Saturday, April 14, targeting what representatives of coalition forces called chemical weapons sites in retaliation for an earlier poison gas attack.