"Our heroic air defences have responded to an aggression with missiles that targeted the Shayrat air base in the Homs countryside and shot them down", Syrian state TV said without specifying the number of missiles or the source of the attack.
Following reports of the missile strikes on April 16, the Israeli military declined to comment.
The Pentagon has denied responsibility for Monday's attack.
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"There is no USA military activity in that area at this time", a Pentagon spokesman, Eric Pahon, said.
A Hezbollah milita media unit shortly afterward stated that Syrian air defenses intercepted three missiles that targeted the Dumayr airport in northeast Damascus.
Damascus skies erupt with surface to air missile fire as the U.S. launches an attack on Syria targeting different parts of the Syrian capital Damascus, Syria, April 14, 2018.
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Pentagon spokesman Eric Pahond said there was "no United States military activity in that area at this time", according to The Jerusalem Post.
A statement from the Syrian regime added that several missiles were intercepted, but these reports are unconfirmed. The US Department of Defense spokesman, meanwhile, told Sky News Arabia that there are "a lot of players" in the region who could have carried out the Tuesday morning attack in Syria. Syria and its allies most recently accused Israel of launching a strike against Syria's T4 airbase in Homs, killing four Iranian military personnel. It also comes roughly a week after two Israeli F-15 fighters targeted another Syria's airbase in Homs province, Tiyas (also known as T-4 Airbase).
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