It also said there may be "intermittent disruption of radio navigation equipment".
Pan-European air control management agency Eurocontrol has issued an urgent warning to airlines, advising of the possibility of missile strikes into Syria and resulting disruption to flight paths.
The statement came after U.S. President Donald Trump announced Monday he would decide within 48 hours how to respond to Saturday's alleged chemical weapons attack by the Syrian regime in Douma, Syria.
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The move comes as Russian Federation, on Tuesday evening, vetoed a U.S. proposal for an investigation into an alleged chemical weapons attack in Syria.
Some major airlines were re-routing flights on Wednesday.
Trump on Tuesday canceled a planned trip to Latin America later this week to focus on responding to the Syria incident, the White House said. It did not specify where the missile threat might originate.
According to the Flightradar24 portal, now in the sky over Syria, air transportation has been practically ceased.
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At other periods later in the day, there were no flights using the airspace.
The Eurocontrol statement included a broader area outside the airspace controlled by Damascus.
There has been heightened awareness by regulators and airlines of the risks that conflict zones pose to commercial jets since Malaysia Airlines flight MH17 was shot down by a surface-to-air missile over Ukraine in 2014, killing all 298 people on board.
In 2017, North Korea tested missiles without warning, leading many airlines to change flight routes to avoid areas around the Sea of Japan.
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