Adrian Kajumba of the Daily Mirror reported Tuesday Kane has been ruled out "until May and faces a desperate battle to be fully fit" for this summer's tournament in Russian Federation.
Kane turned his ankle in a challenge with Asmir Begovic.
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According to reports in the British media on Tuesday, the injury is serious enough that Kane is facing a race against time to return to action in time for the World Cup in June.
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That would mean Kane would return for the final few games of Spurs' Premier League season and would have only a few matches to build his fitness ahead of England's World Cup run in Russian Federation this summer.
He left the ground on crutches and had to postpone a scan due to the amount of swelling.
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Kane, who has scored 35 times for Tottenham this season, would only have a handful of matches remaining this term to prove his fitness to England manager Gareth Southgate.