Daniel, ranked 109 in the world, claimed the biggest win of his career as the qualifier prevailed 7-6 (7/3), 4-6, 6-1. He lost to Chung Hyeon in the Australian Open fourth round in January before undergoing the surgery.
Nadal is now out with a recurrence of his hip injury, Djokovic is struggling after elbow problems and Murray is recovering from major surgery in January.
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Other seeded players who lost were ninth-seeded Lucas Pouille, who fell 6-4, 6-4 to Yuki Bhambri; 14th-seeded Diego Schwartzman, 7-5, 6-4 to Marcos Baghdatis; 21st-seeded Kyle Edmund, 6-4, 6-4 to Dudi Sela; and number 24 seed Giles Muller, 6-3, 7-5 to Pierre-Hugues Herbert.
"To me, it's not that surprising", Federer said.
"It feels insane. I mean, I'm still in shock", Anisimova said.
Federer returned to stadium court on Sunday afternoon and needed an hour to finish off his second round victory 6-3, 7-6 (8-6).
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Playing for a third consecutive day due to weather delays, the 36-year-old Swiss showed no sign of wear en route to a 6-2, 6-1 thrashing of the Serbian in the pair's first ever meeting. "Back in the day, I used to play six matches in a row". "When you go away from the game for, let's say, over a two-month period maybe, it starts feeling a little bit that way".
"Look, still such early stages for Novak coming back and the first one after surgery".
"When you do come back from injury or when you haven't played in a long time, it just takes extra effort. He's only going to get better from here".
"I was attacking when I had my chances and controlling most of the times the points", said Cilic. That comes over playing a good schedule with the right amount of practice, vacation, matches, everything. "Now we're in Indian Wells and that's my focus and not what I have achieved in the past".
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