Three second-half goals led to Villa running out 4-1 winners in the West Midlands derby, leaving leaders Wolves with just a seven-point advantage over their local rivals.
Luke Freeman added a late third at Villa Park to move QPR up to 15th despite James Chester's consolation - the defender's third goal in three games.
Albert Adomah gave Villa the flawless start with a close-range strike in the eighth minute before Diogo Jota equalised ten minutes later but then two goals in five second-half minutes swung things in Villa's favour.
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"We had all of that in abundance today and were backed by a wonderful crowd".
Vexed supporters of the Molineux club took to social media to vent about the Villa boss. I blame myself because I always thought it would be hard to get the bandwagon rolling again.
"I'd say given the context of the game, it's the best result since I've been here".
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The Bosnian striker scored the only goal of the second leg to put the Serie A side through on away goals against Shakhtar. The 31-year-old has now been directly involved in six of Roma's Champions League goals this season.
Steve Bruce's side, having thrashed the leaders Wolves 4-1 on Saturday, fell behind to Ryan Manning's header after 12 minutes and Jake Bidwell's deflected effort put the visitors 2-0 up at half-time. "They know that all the pressure is on the big clubs because of the expectation on their players".
"If I'd have done a wishlist years ago I couldn't have asked for much more - perhaps being 30 points clear at the top would have been nice, but unfortunately that's not the case!"
"But there's still some way to go and Tuesday will now be a more hard game than today".
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Nicol said on ESPN FC when asked who is the best behind Guardiola: "Obviously I would go with Klopp. That didn't happen, but everyone can see that the way is positive at least.
The Wolves game was a great night for everyone connected with Villa and there will be a feel-good factor around the place tonight. It's a bad feeling but we've got a game on Tuesday, we've got to look up, get ready for that and really go again.