Liverpool have won the ball in the centre more than any other team and they need to stop City from passing their way through midfield - by matching City's high-intensity and press high, forcing them to play long balls.
This season, the Reds are currently fourth in the league thanks to the form of Mohamed Salah, Roberto Firmino, Sadio Mane and the now-departed Philippe Coutinho, and have qualified for the last 16 in the Champions League, where they will face FC Porto.
His Spurs side produced four wins, a draw and a single defeat to Guardiola's City, who remain unbeaten in the Premier League and sit 15 points clear at the top.
This time they will have Virgil van Dijk in their way with the Liverpool defender set to make his Premier League debut after his move from Southampton.
"I think Liverpool play like Liverpool was in the past, in all their history".
"I would have liked to see that game without Mane getting sent off because Liverpool were well in the game before that and it would have been interesting" said Henry. The Over-Under, or total number of goals oddsmakers think will be scored, is 3, unchanged from the open. "But Liverpool was the team that up until the sending-off you were like, 'there is something here'".
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We fancy the big center-back to do just that and give Pep Guardiola's side their first loss of the Premier League season.
Who will come out on top between Van Dijk and Sergio Aguero?
"This season at Stamford Bridge we were able to do that but still we have to go to Anfield, to Emirates and against Tottenham".
Guardiola played down City's poor record at Anfield, where they have not won in years. They are only looking at more reinforcements to further strengthen the team.
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There have only been five longer unbeaten streaks in the top flight than City's current run of 30 matches. Pick your XI using our interactive team selector.
You won't hear many City fans complaining but since the club takeover by Abu Dhabi United Group for £210 in 2008, it's been spend, spend, spend and win, win, win.
Sane did not consider quitting the Veltins-Arena to join Borussia Dortmund as a youngster, though, and he also rejected advances from Liverpool ahead of agreeing to sign for Man City 18 months ago.
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There was Sterling's late equaliser for City's 10 men against Everton.
The 26-year-old midfielder has, however, suggested that he will be committing to the Premier League leaders as he is feeling settled at the Etihad Stadium.
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