Ibuprofen Use Linked to Compensated Hypogonadism in Males

Male infertility among many side effects linked to ibuprofen- study

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Danish researchers studied men aged between 18 and 35 who had no fertility problems before the research. In the new study, researchers found that prolonged, high-dosage use of ibuprofen may cause changes to levels of so-called "luteinizing hormones", which induce the testicles to produce testosterone.

Taking a common painkiller can disrupt men's hormones and cause a disorder associated with impaired fertility, CNN reports.

Compensated hypogonadism has been linked to infertility and depression, as well as heart attacks and other cardiovascular problems.

According to Bernard Jégou, co-author and director of the Institute of Research in Environmental and Occupational Health in France, the new study is a continuation of research that began with pregnant women.

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Speaking to Turkish daily Habertürk, Physical Therapy and Rehabilitation Specialist Özgül Bozkurt Tuncer said that Ibuprofen is regularly used in the field of rehabilitation, but she prefers not to prescribe it due to its short-term effects on the kidneys and liver. The effect was apparent at two weeks and became more pronounced after six weeks of ibuprofen use. Ibuprofen is a common drug used for pain relieving especially by athletes.

The painkiller does not affect testosterone directly - but sex hormones that regulate testosterone's production.

Tots were up to 16 times more likely to have undescended testicles if their mum took more than one dose of aspirin, paracetamol or ibuprofen when expecting. Ibuprofen, also known as an non-steroidal anti-inflammatory drug, has a negative impact on the testicles of young men, according to CNN.

The findings of Jegou and scientists from the University of Copenhagen were published on Monday in the U.S. journal Proceedings of the National Academy of Sciences.

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Again, it's important to emphasize this was a really small study that required two weeks of constant ibuprofen use before there was any indication that something was out of the ordinary. The authority people of the manufacturing company tells that this product is tested and based on scientific study. However, it remains unknown whether the health effects of long-term ibuprofen use are reversible, he said.

"The major concern is of course male fertility and how it is affected by chronic use".

"But no direct effect on fertility was shown, but the results of this initial study suggest that it warrants further investigation".

Based on the results, researchers don't recommend taking ibuprofen for longer than the 10 days it says on the packet.

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